Nanofiber Scaffold-Based Tissue-Engineered Retinal Pigment Epithelium to Treat Degenerative Eye Diseases
نویسندگان
چکیده
منابع مشابه
Retinal pigment epithelium-retina transplantation for retinal degenerative disease.
U N C O R R EC N THIS ISSUE OF THE JOURNAL, RADTKE AND ASSOCIates report on the results of a phase 2 clinical trial of fetal retinal pigment epithelium (RPE)–retina translantations in patients with retinitis pigmentosa (RP) and ge-related macular degeneration (AMD). Visual acuity VA) improved in seven of 10 study eyes and in three of 10 ellow control eyes. Some issues that merit consideration r...
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Adult human retinal pigment epithelium has been enzymatically isolated and established In tissue culture. Primary cultures survived three to six months. Occasionally, cell lines spontaneously evolved from primary cultures. Melanin granules decreased with the age of the culture, became less pigmented but retained some characterstics of melanin-producing cells. Lipofuscin granules are present, bu...
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Regenerative strategies for retinal degenerative diseases are limited by poor cellular survival, distribution and integration after transplantation to the sub-retinal space. To overcome this limitations a stem cell delivery system was developed, taking advantage of the minimally-invasive, injectable and biodegradable properties of a blend of hyaluronan and methylcellulose (HAMC). The physical a...
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ژورنال
عنوان ژورنال: Journal of Ocular Pharmacology and Therapeutics
سال: 2016
ISSN: 1080-7683,1557-7732
DOI: 10.1089/jop.2015.0157